基于P18双亲性多肽分子的SDT抗肿瘤摘要： 光动力疗法应用于人类肿瘤研究已有 30 年历史，随着一些光敏剂具有的声敏性被发现，声动力疗法便受到相关领域学者的关注。
通过在声光领域对光动力疗法和声动力疗法杀伤肿瘤细胞机制的研究，发现两者可通过各自独特方式产生相似的活性氧类物质，继而启动相关凋亡通路来杀伤肿瘤细胞;另一方面组织蛋白酶 B广泛存在于哺乳动物的各种器官中，不仅参与细胞凋亡和自噬的全过程，而且与肿瘤的侵袭和扩散密切相关。
它通过水解黏连在细胞间的蛋白质，加速癌细胞的转移和肿瘤内血管的生成。
不同分化水平的癌细胞组织蛋白酶表达不同，所以，本研究设计开发含有组织蛋白酶B序列的两亲性多肽修饰紫红素18（P18）以改善P18的疏水性，并且检测癌细胞组织蛋白酶B 水平，实现肿瘤的光动力治疗。
关键词： 光动力治疗；声动力治疗；组织蛋白酶B；两亲性多肽；紫红素18Sonodynamic therapy based on P18 amphiphilic polypeptide molecule against tumorAbstract: Over 30 years ago，photodynamic therapy was applied for the study of human tumor，and with the discovery of some photosensitizer having ultrasonic sensitivity，the sonodynamic therapy has drawn concerns from some scholars in related fields． Through investigating the mechanisms of killing tumor cells by photodynamic and sonodynamic therapy in respective areas，experts discovered that they could produce similar reactive oxygen species in their own way，and then kill tumor cells by activating the related apoptosis pathway．Cathepsin B is a cysteine protease, which is widely found in many tissues of various mammals,and is one of the best-studied protease. Cathepsin B is involved in cell apoptosis, autophagy and cancer development, and therefore is a potential target for cancer protection. Researches suggest that cathepsin B is closely related to a variety of cancers, including breast cancer, gastric cancer, lung cancer, and bladder cancer.Tumor tissues are detected with a significant rise of cathepsin B, which shows that cathepsin B has a important role in tumor proliferation and can be used as an potential biomarker of cancer. Cathepsin B helps tumor cells to metastasize and angiogenesis by hydrolysis of proteins.Phosphorothioate 18 (P18) modified with an amphipathic peptide improves the hydrophobicity of P18 for the photodynamic therapy of tumors.Keywords:photodynamic therapy; sonodynamic therapy; cathepsin B; amphiphilic polypeptide; purpurin 181癌症治疗现状癌症，是当今严重威胁人类健康的主要疾病之一，有效地治疗癌症对于提高患者的生存质量、减轻患者的痛苦、降低死亡率具有十分重要的意义。
现今，化疗是肿瘤治疗中不可缺少的重要方法之一。
但是，由于目前临床用于肿瘤治疗的大多数化疗药物显示出低的水溶性、有限的稳定性、快速的血液清除和缺乏对肿瘤部位的靶向性，进入体内后肿瘤组织与正常组织都有分布，因此在杀伤肿瘤细胞的同时也损伤了人体正常组织细胞，从而导致疗效低、毒副作用强等缺点。
2.光动力疗法（PDT）和声动力疗法（SDT）而近年来，针对癌症的治疗出现了两种新方法，光动力疗法（PDT）和声动力疗法（SDT），并且已成为肿瘤防治研究中备受关注的课题。
与传统疗法相比，其最大的优势就是可以利用光敏剂或声敏剂通过光学或声学作用产生活性氧（ROS）选择性地杀伤肿瘤细胞，明显减少不良反应［1］ 。
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